The Pantherettes will will take on district rival DeSoto on Tuesday night at 7 p.m. at Grand Prairie High School.
Duncanville defeated Killeen Shoemaker 74-27 in bi-district and Plano West 84-52 in the area playoffs.
DeSoto downed Killeen Ellison 70-50 and Lewisville 43-39 to advance to the regional quarterfinals.
Duncanville has defeated DeSoto twice this year already in district 7-6A action, 52-43 and 63-48.
Duncanville is currently ranked as the #1 6A girls team in the Texas Association of Basketball Coaches (TABC) latest ranking. While DeSoto remains unranked in that same poll.